Histone H4 Transcription Factor (HINFP) Antibody – Rabbit Polyclonal

MIZF: a transcriptional regulator of cell cycle-controlled histone H4 genes at the onset of S phase. Also activates transcription of the ATM and PRKDC genes. A histone H4-specific transcriptional regulator that associates with the cell cycle control element in the conserved proximal promoter regions of H4 genes. Interacts with NPAT to coactivate H4 gene transcription at the G1/S phase transition in response to cyclin E/CDK2 signaling. HiNF-P/NPAT colocalize to Cajal bodies in a cell cycle-specific manner. Disruption of the HiNF-P/NPAT interaction inhibits histone H4 gene expression at G1/S. Binds methyl-CpG-binding protein (MeCP2) and a histone deacetylase complex.

Protein type: C2H2-type zinc finger protein; Cell cycle regulation; Histone-binding

Cellular Component: nucleoplasm; Cajal body; nucleus

Molecular Function: enzyme binding; DNA binding; nucleic acid binding; histone binding; metal ion binding; transcription coactivator activity; chromatin binding; transcription factor activity

Biological Process: myoblast differentiation; G1/S-specific transcription in mitotic cell cycle; establishment of protein localization; regulation of transcription, DNA-dependent; transcription, DNA-dependent; regulation of gene expression; in utero embryonic development; positive regulation of transcription, DNA-dependent; DNA damage checkpoint; negative regulation of transcription from RNA polymerase II promoter; DNA repair; negative regulation of transcription, DNA-dependent; G1/S transition of mitotic cell cycle