Kinesin Family Member 1b (KIF1B) Antibody – Rabbit Polyclonal

KIF1B: a member of the kinesin motor protein family. Motor for anterograde transport of mitochondria. May play a role in synaptic vesicle transport. Has a microtubule plus end-directed motility. Aberrant expression seen in neuroblastoma. Mutated in Charcot-Marie-Tooth disease.

Protein type: Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 1p36.2

Cellular Component: microtubule; kinesin complex; neuron projection; microtubule associated complex; cytoplasmic vesicle membrane; mitochondrion; cytoplasmic vesicle

Molecular Function: protein binding; kinesin binding; plus-end-directed microtubule motor activity; microtubule binding; ATPase activity; microtubule motor activity; ATP binding

Biological Process: vesicle-mediated transport; apoptosis; metabolic process; neuromuscular synaptic transmission; nerve-nerve synaptic transmission; cytoskeleton-dependent intracellular transport; anterograde axon cargo transport; microtubule-based movement; mitochondrion transport along microtubule

Disease: Charcot-marie-tooth Disease, Axonal, Type 2a1; Neuroblastoma, Susceptibility To; Pheochromocytoma