Wd Repeat Domain 45 (WDR45) Antibody – Rabbit Polyclonal

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]

WDR45: a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]

Protein type: Autophagy

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: extrinsic to membrane; pre-autophagosomal structure membrane; cytosol

Molecular Function: phosphatidylinositol 3-phosphate binding

Biological Process: protein amino acid lipidation; mitochondrion degradation; autophagy; cellular response to nitrogen starvation; autophagic vacuole formation

Disease: Neurodegeneration With Brain Iron Accumulation 5