Sorting Nexin 9 (SNX9) Antibody – Rabbit Polyclonal

This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. [provided by RefSeq, Jul 2013]

SNX9: May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F- actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. Belongs to the sorting nexin family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: ruffle; extrinsic to internal side of plasma membrane; cytoplasmic vesicle membrane; clathrin-coated vesicle; cytoplasm; cytoplasmic membrane-bound vesicle; plasma membrane; trans-Golgi network; endosome

Molecular Function: protein binding; protein homodimerization activity; ubiquitin protein ligase binding; phosphoinositide binding; phosphatidylinositol binding

Biological Process: mitosis; intracellular protein transport; receptor-mediated endocytosis; positive regulation of protein oligomerization; cytokinesis after mitosis; vesicle organization and biogenesis; positive regulation of protein kinase activity; endocytosis; endosome transport; positive regulation of membrane protein ectodomain proteolysis; positive regulation of GTPase activity