Complexin 1 (CPLX1) Antibody – Rabbit Polyclonal

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]

CPLX1: Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Belongs to the complexin/synaphin family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: cell soma; dendrite; synapse; cytosol

Molecular Function: syntaxin-1 binding; neurotransmitter transporter activity

Biological Process: regulation of exocytosis; synaptic transmission; synaptic vesicle exocytosis; exocytosis; glutamate secretion; insulin secretion; neurotransmitter secretion

Disease: Wolf-hirschhorn Syndrome