Integrin Beta 1 Binding Protein 1 (ITGB1BP1) Antibody – Rabbit Polyclonal

The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. [provided by RefSeq, Jul 2008]

ICAP1: May play a role in the recruitment of beta-1 integrins to the focal contacts during integrin-dependent cell adhesion. Isoform 2 does not bind the integrin cytoplasmic domain-associated protein-1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 2p25.2

Cellular Component: ruffle; cytoskeleton; focal adhesion; membrane; lamellipodium; perinuclear region of cytoplasm; cytoplasm; plasma membrane; cytosol; nucleus

Molecular Function: integrin binding; protein binding; GDP-dissociation inhibitor activity; protein complex binding; protein kinase binding; protein transporter activity

Biological Process: integrin activation; cell-matrix adhesion; receptor clustering; negative regulation of cell proliferation; regulation of cell adhesion mediated by integrin; protein transport; positive regulation of focal adhesion formation; biomineral formation; positive regulation of cell proliferation; positive regulation of stress fiber formation; negative regulation of protein binding; regulation of blood vessel size; cell differentiation; positive regulation of Notch signaling pathway; integrin-mediated signaling pathway; Notch signaling pathway; substrate-bound cell migration, cell release from substrate; cell migration; transcription, DNA-dependent; activation of protein kinase B; negative regulation of focal adhesion formation; lumen formation; positive regulation of protein kinase B signaling cascade; blood vessel endothelial cell proliferation during sprouting angiogenesis; positive regulation of cell division; myoblast migration; negative regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter