TATA Element Modulatory Factor 1 (TMF1) Antibody – Rabbit Polyclonal

TMF1: Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 3p14.1

Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum; nucleus

Molecular Function: protein binding; DNA binding; transcription cofactor activity

Biological Process: positive regulation of cytokine production; acrosome formation; transcription from RNA polymerase II promoter; luteinizing hormone secretion; sperm motility; Leydig cell differentiation; regulation of transcription, DNA-dependent; defense response to bacterium; spermatid nuclear differentiation; negative regulation of apoptosis