High-Mobility Group 20a (HMG20A) Antibody – Rabbit Polyclonal

HMG20A: Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase MLL and consequent increased methylation of histone H3 lysine 4. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: nucleus

Molecular Function: protein binding; DNA binding; protein heterodimerization activity; chromatin binding; transcription factor activity

Biological Process: chromatin remodeling; negative regulation of neuron differentiation; establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter