Ubiquitin Specific Peptidase 16 (USP16) Antibody – Rabbit Polyclonal

This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

USP16: a ubiquitous ubiquitin-processing protease that may de-ubiquitinate one or more critical proteins that are involved in the condensation of mitotic chromosomes, possibly acting selectively on histones H2A and H2B, the major ubiquitinated proteins of chromatin. Is phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition.

Protein type: Ubiquitin-specific protease; EC 3.4.19.12; Ubiquitin conjugating system; Protease

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: cytoplasm; nucleus

Molecular Function: ubiquitin binding; histone binding; zinc ion binding; cysteine-type endopeptidase activity; transcription coactivator activity; ubiquitin-specific protease activity

Biological Process: regulation of transcription from RNA polymerase II promoter; mitosis; proteasomal ubiquitin-dependent protein catabolic process; transcription, DNA-dependent; cell division; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of translational elongation; cell cycle; response to DNA damage stimulus; histone deubiquitination; protein homotetramerization