Wd Repeat Domain 77 (WDR77) Antibody – Polyclonal

WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).[supplied by OMIM, Mar 2008]

WDR77: a WD40 repeat protein. Component of the methylosome, a 20S complex containing at least ICLN, SKB1 and WDR77. Interacts with SKB1 and with SM proteins. The methylosome may regulate an early step in the assembly of U snRNPs, possibly the transfer of Sm proteins to the SMN-complex. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; ligand-dependent nuclear receptor transcription coactivator activity

Biological Process: regulation of transcription from RNA polymerase II promoter; spliceosomal snRNP biogenesis; establishment and/or maintenance of chromatin architecture; positive regulation of cell proliferation; gene expression