Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) Antibody – Rabbit Polyclonal

TNKS: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 2.4.2.30

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: Golgi membrane; Golgi apparatus; spindle pole; chromosome, telomeric region; pericentriolar material; nuclear membrane; nuclear chromosome, telomeric region; nuclear pore; cytosol; chromosome, pericentric region

Molecular Function: protein binding; zinc ion binding; NAD+ ADP-ribosyltransferase activity

Biological Process: mitosis; mRNA transport; Wnt receptor signaling pathway; protein polyubiquitination; peptidyl-threonine phosphorylation; spindle assembly; negative regulation of DNA binding; positive regulation of telomere maintenance via telomerase; protein transport; protein amino acid ADP-ribosylation; peptidyl-serine phosphorylation; mitotic spindle organization and biogenesis; cell division; positive regulation of transcription from RNA polymerase II promoter; regulation of telomere maintenance via telomerase