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PPFIA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS713511

MBS713511 is an antibody targeting PPFIA1. Also known as Rabbit anti-human protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$590 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 (PPFIA1), Polyclonal Antibody
Full Product Name
Rabbit anti-human protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 polyclonal Antibody
Product Gene Name
anti-PPFIA1 antibody
Product Synonym Names
protein tyrosine phosphatase; receptor type; f polypeptide (PTPRF); interacting protein (liprin); alpha 1; PPFIA1; FLJ41337; FLJ42630; FLJ43474; LIP.1; LIP1; LIPRIN; MGC26800
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Molecular Weight
133,970 Da
OMIM
611054
Immunogen
Human PPFIA1
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-54037 / sc-54038 / sc-54039 / sc-54040 / sc-67262
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PPFIA1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Other Notes

Small volumes of anti-PPFIA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PPFIA1. It may not necessarily be applicable to this product.

NCBI GI #
21707845
NCBI GeneID
8500
NCBI Accession #
AAH34046.1
UniProt Secondary Accession #
Q13135; Q14567; Q8N4I2; A6NLE3
UniProt Related Accession #
Q13136
NCBI Official Full Name
Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
NCBI Official Synonym Full Names
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
NCBI Official Symbol
PPFIA1
NCBI Official Synonym Symbols
LIP1; LIP.1; LIPRIN
UniProt Protein Name
Liprin-alpha-1
UniProt Synonym Protein Names
LAR-interacting protein 1; LIP-1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1; PTPRF-interacting protein alpha-1
Protein Family
Liprin
UniProt Gene Name
PPFIA1
UniProt Synonym Gene Names
LIP1; LIP-1; PTPRF-interacting protein alpha-1
UniProt Entry Name
LIPA1_HUMAN
NCBI Protein Information
liprin-alpha-1; LIP-1; Liprin-alpha1; LAR-interacting protein 1; PTPRF-interacting protein alpha-1; protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1

NCBI Summary for PPFIA1

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
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UniProt Comments for PPFIA1

liprin alpha 1: a ubiqutous member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Two alternatively spliced isoforms have been described.

Protein type: Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: focal adhesion; cytoplasm; presynaptic active zone; cytosol

Molecular Function: protein binding; signal transducer activity

Biological Process: synaptic transmission; negative regulation of stress fiber formation; glutamate secretion; neurotransmitter secretion; cell-matrix adhesion; signal transduction
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Research Articles on PPFIA1

1. PPFIA1 was frequently co-amplified with the Cyclin D1 gene in oral carcinomas and could present a biomarker as well as a novel target for specific gene therapy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PPFIA1 antibody

 Reference Product  PubMed Publications
 PTPRF antibody  >8 publications with PPFIA1 and PTPRF
 PTPRD antibody  >7 publications with PPFIA1 and PTPRD
 ING4 antibody  >2 publications with PPFIA1 and ING4
 PPP2CB antibody  >1 publications with PPFIA1 and PPP2CB
 PTPRS antibody  >1 publications with PPFIA1 and PTPRS
 PPP2CA antibody  >1 publications with PPFIA1 and PPP2CA

Pathways associated with anti-PPFIA1 antibody

 Products by Pathway  Pathway Diagram
 Acetylcholine Neurotransmitter Release Cycle Pathway antibodies  Acetylcholine Neurotransmitter Release Cycle Pathway Diagram
 Dopamine Neurotransmitter Release Cycle Pathway antibodies  Dopamine Neurotransmitter Release Cycle Pathway Diagram
 Glutamate Neurotransmitter Release Cycle Pathway antibodies  Glutamate Neurotransmitter Release Cycle Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Release Cycle Pathway antibodies  Neurotransmitter Release Cycle Pathway Diagram
 Norepinephrine Neurotransmitter Release Cycle Pathway antibodies  Norepinephrine Neurotransmitter Release Cycle Pathway Diagram
 Serotonin Neurotransmitter Release Cycle Pathway antibodies  Serotonin Neurotransmitter Release Cycle Pathway Diagram
 Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram

Diseases associated with anti-PPFIA1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with PPFIA1 and Nervous System Diseases
 Mental Disorders Antibodies  >2 publications with PPFIA1 and Mental Disorders
 Embryo Loss Antibodies  >1 publications with PPFIA1 and Embryo Loss
 Fibrosis Antibodies  >1 publications with PPFIA1 and Fibrosis
 Seizures Antibodies  >1 publications with PPFIA1 and Seizures
 Inflammation Antibodies  >1 publications with PPFIA1 and Inflammation

Organs/Tissues associated with anti-PPFIA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with PPFIA1 and Brain
 Nerve Antibodies  >7 publications with PPFIA1 and Nerve
 Mouth Antibodies  >3 publications with PPFIA1 and Mouth
 Embryonic Tissue Antibodies  >3 publications with PPFIA1 and Embryonic Tissue
 Bladder Antibodies  >3 publications with PPFIA1 and Bladder
 Eye Antibodies  >2 publications with PPFIA1 and Eye
 Mammary Gland Antibodies  >2 publications with PPFIA1 and Mammary Gland
 Liver Antibodies  >2 publications with PPFIA1 and Liver
 Muscle Antibodies  >2 publications with PPFIA1 and Muscle
 Skin Antibodies  >2 publications with PPFIA1 and Skin
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