Monoamine Oxidase B (MAOB) Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]

MAOB: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. Belongs to the flavin monoamine oxidase family.

Protein type: Mitochondrial; Amino Acid Metabolism - histidine; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - arginine and proline; EC 1.4.3.4; Oxidoreductase; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; Membrane protein, integral; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: mitochondrial envelope; mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; integral to membrane

Molecular Function: amine oxidase activity; protein homodimerization activity; FAD binding; electron carrier activity

Biological Process: response to drug; dopamine catabolic process; response to toxin; response to lipopolysaccharide; negative regulation of serotonin secretion; positive regulation of dopamine metabolic process; response to selenium ion; response to ethanol; substantia nigra development; xenobiotic metabolic process; hydrogen peroxide biosynthetic process; response to aluminum ion; response to corticosterone stimulus