Protein Tyrosine Phosphatase, Receptor Type, J (PTPRJ) Antibody – Rabbit Polyclonal

PTPRJ: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 3.1.3.48; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: nucleoplasm; cell surface; integral to plasma membrane; plasma membrane; immunological synapse; intercellular junction; cell junction

Molecular Function: protein binding; gamma-catenin binding; phosphoric monoester hydrolase activity; beta-catenin binding; platelet-derived growth factor receptor binding; mitogen-activated protein kinase binding; protein tyrosine phosphatase activity; protein kinase binding

Biological Process: regulation of cell adhesion; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of protein kinase B signaling cascade; positive regulation of cell adhesion; heart development; negative regulation of T cell receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; negative regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; positive chemotaxis; positive regulation of focal adhesion formation; negative regulation of vascular permeability; oligodendrocyte differentiation; negative regulation of cell growth; vasculogenesis; blood coagulation; negative regulation of cell migration

Disease: Colorectal Cancer