PRP19/PSO4 Pre-Mrna Processing Factor 19 Homolog (PRPF19) Antibody – Rabbit Polyclonal

PRPF19: Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Belongs to the WD repeat PRP19 family.

Protein type: RNA splicing; EC 6.3.2.19; Ligase; Ubiquitin ligase; Ubiquitin conjugating system; Spliceosome; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 11q12.2

Cellular Component: nucleoplasm; DNA replication factor A complex; membrane; cytoplasm; spindle; lipid particle; nuclear speck; nucleus

Molecular Function: identical protein binding; protein binding; ligase activity

Biological Process: assembly of spliceosomal tri-snRNP; proteasomal protein catabolic process; protein polyubiquitination; RNA splicing; lipid biosynthetic process; inner cell mass cell proliferation; generation of catalytic spliceosome for first transesterification step; double-strand break repair via nonhomologous end joining; positive regulation of nuclear mRNA splicing, via spliceosome; nuclear mRNA splicing, via spliceosome; negative regulation of neuron differentiation; spliceosome assembly; gene expression; positive regulation of astrocyte differentiation