Myb-Like, SWIRM and MPN Domains 1 (MYSM1) Antibody – Rabbit Polyclonal

MYSM1: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Belongs to the peptidase M67A family. MYSM1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin-specific protease; EC 3.4.19.-; Ubiquitin conjugating system; Protease

Chromosomal Location of Human Ortholog: 1p32.1

Cellular Component: microtubule cytoskeleton; nucleoplasm; nucleus

Molecular Function: DNA binding; metallopeptidase activity; histone binding; metal ion binding; transcription coactivator activity; ubiquitin-specific protease activity; protein complex binding; chromatin binding

Biological Process: chromatin remodeling; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; proteolysis