RNA Binding Motif Protein 9 (RBFOX2) Antibody – Rabbit Polyclonal

RBM9: RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. RNA-binding protein that seems to act as a coregulatory factor of ER-alpha. 10 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; RNA-binding; RNA splicing

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: mRNA binding; protein binding; RNA binding; nucleotide binding; transcription factor binding; transcription corepressor activity

Biological Process: estrogen receptor signaling pathway; RNA metabolic process; dendrite morphogenesis; radial glia guided migration of Purkinje cell; RNA splicing; mRNA processing; negative regulation of transcription, DNA-dependent; neuromuscular process controlling balance; regulation of alternative nuclear mRNA splicing, via spliceosome; regulation of cell proliferation