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Rho Gtpase Activating Protein 24 (ARHGAP24) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS714207

MBS714207 is an antibody targeting ARHGAP24. Also known as Rabbit anti-human Rho GTPase activating protein 24 polyclonal Antibody. Reactive in Human, Mouse, Rat, Dog, Zebrafish. Host: Rabbit. Purified Rabbit Anti Human, Mouse PolyClonal Antibody More details

$590 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Rho GTPase activating protein 24 (ARHGAP24), Polyclonal Antibody
Full Product Name
Rabbit anti-human Rho GTPase activating protein 24 polyclonal Antibody
Product Gene Name
anti-ARHGAP24 antibody
Product Synonym Names
Rho GTPase activating protein 24;ARHGAP24;DKFZp564B1162;FILGAP;FLJ33877;RCGAP72; RCGAP72;p73;p73RhoGAP ;FILGAP
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Dog, Zebrafish
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
OMIM
610586
Conjugated
Non-conjugated
Immunogen
Human ARHGAP24
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ARHGAP24 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Other Notes

Small volumes of anti-ARHGAP24 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ARHGAP24. It may not necessarily be applicable to this product.

NCBI GI #
111154092
NCBI GeneID
83478
NCBI Accession #
NP_001020787.2
UniProt Secondary Accession #
Q4KMG1; Q6ZNV3; Q86TI5; Q86WE4; Q9H0T6
UniProt Related Accession #
Q8N264
GenBank Nucleotide #
NM_001025616.2
NCBI Official Full Name
rho GTPase-activating protein 24 isoform 1
NCBI Official Synonym Full Names
Rho GTPase activating protein 24
NCBI Official Symbol
ARHGAP24
NCBI Official Synonym Symbols
p73; FILGAP; RCGAP72; RC-GAP72; p73RhoGAP
UniProt Protein Name
Rho GTPase-activating protein 24
UniProt Synonym Protein Names
Filamin-A-associated RhoGAP; FilGAP; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa; RC-GAP72; Rho-type GTPase-activating protein 24; RhoGAP of 73 kDa; Sarcoma antigen NY-SAR-88; p73RhoGAP
Protein Family
Rho GTPase-activating protein
UniProt Gene Name
ARHGAP24
UniProt Synonym Gene Names
FILGAP; FilGAP; RC-GAP72
UniProt Entry Name
RHG24_HUMAN
NCBI Protein Information
rho GTPase-activating protein 24; rhoGAP of 73 kDa; sarcoma antigen NY-SAR-88; filamin-A-associated RhoGAP; rho-type GTPase-activating protein 24; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa

NCBI Summary for ARHGAP24

ARHGAPs, such as ARHGAP24, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]

UniProt Comments for ARHGAP24

ARHGAP24: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, Rac/Rho; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q22.1

Cellular Component: focal adhesion; cell projection; cytoskeleton; cytosol

Molecular Function: protein binding

Biological Process: negative regulation of Rac protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; angiogenesis; cell differentiation; wound healing, spreading of epidermal cells
Show more

Research Articles on ARHGAP24

1. Polymorphism rs346473 in the ARHGAP24 gene might be a part of the genetic variants.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ARHGAP24 antibody

 Reference Product  PubMed Publications
 FLNA antibody  >6 publications with ARHGAP24 and FLNA
 CDC42 antibody  >4 publications with ARHGAP24 and CDC42
 RAC1 antibody  >3 publications with ARHGAP24 and RAC1
 SCN10A antibody  >1 publications with ARHGAP24 and SCN10A

Pathways associated with anti-ARHGAP24 antibody

 Products by Pathway  Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram

Diseases associated with anti-ARHGAP24 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >2 publications with ARHGAP24 and Liver Diseases
 Edema Antibodies  >2 publications with ARHGAP24 and Edema
 Nervous System Diseases Antibodies  >1 publications with ARHGAP24 and Nervous System Diseases
 Autoimmune Diseases Antibodies  >1 publications with ARHGAP24 and Autoimmune Diseases
 Carcinoma Antibodies  >1 publications with ARHGAP24 and Carcinoma
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with ARHGAP24 and Drug-Related Side Effects and Adverse Reactions
 Poisoning Antibodies  >1 publications with ARHGAP24 and Poisoning
 Kidney Diseases Antibodies  >1 publications with ARHGAP24 and Kidney Diseases
 Breast Neoplasms Antibodies  >1 publications with ARHGAP24 and Breast Neoplasms
 Drug-Induced Liver Injury Antibodies  >1 publications with ARHGAP24 and Drug-Induced Liver Injury

Organs/Tissues associated with anti-ARHGAP24 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3 publications with ARHGAP24 and Lung
 Blood Antibodies  >2 publications with ARHGAP24 and Blood
 Muscle Antibodies  >2 publications with ARHGAP24 and Muscle
 Brain Antibodies  >2 publications with ARHGAP24 and Brain
 Vascular Antibodies  >2 publications with ARHGAP24 and Vascular
 Kidney Antibodies  >2 publications with ARHGAP24 and Kidney
 Heart Antibodies  >1 publications with ARHGAP24 and Heart
 Liver Antibodies  >1 publications with ARHGAP24 and Liver
 Uterus Antibodies  >1 publications with ARHGAP24 and Uterus
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