V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) Antibody – Rabbit Polyclonal

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

Yes: a proto-oncogenic cytosolic tyrosine kinase of the Src family. Expressed at high levels in adult neurons, spermatozoa, platelets, and epithelial cells.

Protein type: Oncoprotein; Protein kinase, TK; EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; Src family

Chromosomal Location of Human Ortholog: 18p11.31-p11.21

Cellular Component: Golgi apparatus; extrinsic to internal side of plasma membrane; focal adhesion; cytoplasm; plasma membrane; microtubule organizing center; actin filament; cytosol

Molecular Function: protein binding; enzyme binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding; epidermal growth factor receptor binding

Biological Process: axon guidance; T cell costimulation; ephrin receptor signaling pathway; protein modification process; innate immune response; glucose transport; regulation of vascular permeability; blood coagulation; cell differentiation; leukocyte migration; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation