Death-Domain Associated Protein (DAXX) Antibody – Rabbit Polyclonal

DAXX: a transcriptional co-regulatory protein. Proposed to mediate activation of the JNK pathway and apoptosis via ASK1 in response to signaling from FAS and TGF-betaR2. Glucose deprivation activates the ASK1-SEK1-JNK1-HIPK1 pathway, relocalizing Daxx from the nucleus to the cytoplasm, where Daxx binds to ASK1, and subsequently leads to ASK1 oligomerization. Interaction with HSP27 may prevent interaction with TGF-betaR2 and ASK1 and block DAXX-mediated apoptosis. Seems to act as a transcriptional co- repressor and inhibits PAX3 and ETS1 through direct protein- protein interaction. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Two alternatively spliced isoforms have been described.

Protein type: Nucleolus; Apoptosis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: heterochromatin; PML body; cytoplasm; nucleolus; cytosol; nucleus; chromosome, pericentric region

Molecular Function: protein binding; protein homodimerization activity; enzyme binding; androgen receptor binding; histone binding; p53 binding; heat shock protein binding; ubiquitin protein ligase binding; receptor signaling protein activity; protein N-terminus binding; transcription factor binding; transcription corepressor activity; protein kinase activator activity; protein kinase binding

Biological Process: chromatin remodeling; nucleosome assembly; cytokinesis after mitosis; viral reproduction; transcription, DNA-dependent; regulation of transcription, DNA-dependent; induction of apoptosis via death domain receptors; regulation of protein ubiquitination; apoptosis; positive regulation of protein kinase activity; androgen receptor signaling pathway; positive regulation of protein amino acid phosphorylation; negative regulation of transcription, DNA-dependent; activation of JNK activity