Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) Antibody – Rabbit Polyclonal

MSK1: an AGC kinase of the RSK family. Has two kinase domains connected by a regulatory linker region. Enzyme activity requires the presence of both kinase domains. Is phosphorylated and activated by Erk as well as p38 MAPK in response to growth factors and cellular stress.

Protein type: Kinase, protein; Protein kinase, AGC; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; RSK family; MSK subfamily

Chromosomal Location of Human Ortholog: 14q31-q32.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding; protein kinase activity

Biological Process: epidermal growth factor receptor signaling pathway; axon guidance; nerve growth factor receptor signaling pathway; positive regulation of histone phosphorylation; MyD88-independent toll-like receptor signaling pathway; histone phosphorylation; stress-activated MAPK cascade; activation of CREB transcription factor; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; toll-like receptor 2 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of transcription, DNA-dependent; negative regulation of cytokine production; toll-like receptor signaling pathway; innate immune response; positive regulation of histone acetylation; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; inflammatory response; negative regulation of transcription, DNA-dependent; toll-like receptor 4 signaling pathway