Lymphoid Enhancer-Binding Factor 1 (LEF1) Antibody – Rabbit Polyclonal

LEF-1: a transcription factor of the TCF/LEF family. Participates in the Wnt signaling pathway and regulates T-cell receptor alpha-C enhancer function. Activates transcription of target genes in the presence of CTNNB1 and EP300. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1. Deletions in LEF1 have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Four human isoforms produced by alternative promoter usage and alternative splicing have been described. Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling.

Protein type: DNA-binding; Transcription factor

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; estrogen receptor activity; histone binding; caspase inhibitor activity; beta-catenin binding; transcription factor binding; protein binding; DNA binding; sequence-specific DNA binding; gamma-catenin binding; estrogen receptor binding; chromatin binding; transcription factor activity; DNA bending activity

Biological Process: skin development; radial glial cell differentiation in the forebrain; hypothalamus development; positive regulation of transcription, DNA-dependent; T-helper 1 cell differentiation; Wnt receptor signaling pathway through beta-catenin; forebrain neuroblast division; forebrain neuron differentiation; response to organic cyclic substance; BMP signaling pathway; negative regulation of interleukin-13 production; cell adhesion; kidney development; neural crest cell migration; regulation of striated muscle development; embryonic limb morphogenesis; organ regeneration; somitogenesis; dentate gyrus development; sensory perception of taste; negative regulation of striated muscle development; positive regulation of cell growth; patterning of blood vessels; regulation of transcription from RNA polymerase II promoter; negative regulation of interleukin-5 production; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; transcription from RNA polymerase II promoter; B cell proliferation; tongue development; negative regulation of interleukin-4 production; paraxial mesoderm formation; response to lithium ion; positive regulation of granulocyte differentiation; alpha-beta T cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of caspase activity; palate development; anatomical structure regression; regulation of cell-cell adhesion; mammary gland development; vasculature development; positive regulation of cell proliferation; positive regulation of cell-cell adhesion; muscle fiber development; Wnt receptor signaling pathway; neutrophil differentiation; hippocampus development; regulation of Wnt receptor signaling pathway; negative regulation of DNA binding; odontogenesis of dentine-containing teeth; formation of radial glial scaffolds; osteoblast differentiation; epithelial to mesenchymal transition; T cell receptor V(D)J recombination; negative regulation of cell-cell adhesion; sprouting angiogenesis; cell development; eye pigmentation; positive regulation of cell migration