Nuclear Receptor Subfamily 2, Group C, Member 1 (NR2C1) Antibody – Rabbit Polyclonal

This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

NR2C1: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid- regulated preadipocyte proliferation. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 12q22

Cellular Component: nucleoplasm; PML body

Molecular Function: protein binding; protein homodimerization activity; DNA binding; zinc ion binding; sequence-specific DNA binding; histone deacetylase binding; steroid hormone receptor activity; receptor activity; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; steroid hormone mediated signaling; positive regulation of retinoic acid receptor signaling pathway; gene expression; negative regulation of transcription from RNA polymerase II promoter