Fasciculation and Elongation Protein Zeta 1 (Zygin I) (FEZ1) Antibody – Rabbit Polyclonal

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

FEZ1: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. Belongs to the zygin family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 11q24.2

Cellular Component: microtubule cytoskeleton; centrosome; microtubule; mitochondrion; axon; dendrite; cytoplasm; plasma membrane

Molecular Function: gamma-tubulin binding; protein binding; protein kinase C binding; protein N-terminus binding

Biological Process: establishment of mitochondrion localization; nervous system development; axon guidance; transport; cell adhesion