Tubulin Folding Cofactor D (TBCD) Antibody – Rabbit Polyclonal

Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]

TBCD: Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase- activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Belongs to the TBCD family. 5 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: microtubule; adherens junction; tight junction; cytoplasm; lateral plasma membrane

Molecular Function: protein binding; chaperone binding; beta-tubulin binding; GTPase activator activity

Biological Process: 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; negative regulation of microtubule polymerization; transmembrane transport; post-chaperonin tubulin folding pathway; positive regulation of GTPase activity