Annexin A9 (ANXA9) Antibody – Rabbit Polyclonal

The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact. [provided by RefSeq, Jul 2008]

ANXA9: a calcium/phospholipid-binding protein that may act as a low affinity receptor for acetylcholine. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Calcium-binding; Lipid-binding

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cell surface; cytosol

Molecular Function: protein binding; protein homodimerization activity; calcium-dependent phospholipid binding; phosphatidylserine binding; acetylcholine receptor activity; phospholipid binding; calcium ion binding

Biological Process: synaptic transmission; cell-cell adhesion