Transforming Protein Rhoa (RhoA) Antibody – Rabbit Polyclonal

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

RHOA: a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders.

Protein type: Oncoprotein; G protein, monomeric; G protein; Motility/polarity/chemotaxis; G protein, monomeric, Rho

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: apical junction complex; cell cortex; cell junction; cleavage furrow; cytoskeleton; cytosol; endoplasmic reticulum membrane; endosome; focal adhesion; lamellipodium; midbody; plasma membrane; vesicle

Molecular Function: GTP binding; GTPase activity; myosin binding; protein binding

Biological Process: actin cytoskeleton organization and biogenesis; apical junction assembly; axon guidance; blood coagulation; endothelial cell migration; ephrin receptor signaling pathway; negative chemotaxis; negative regulation of axonogenesis; nerve growth factor receptor signaling pathway; phosphoinositide-mediated signaling; platelet activation; positive regulation of axonogenesis; positive regulation of cytokinesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of lipase activity; positive regulation of neuron differentiation; positive regulation of NF-kappaB import into nucleus; positive regulation of stress fiber formation; regulation of actin cytoskeleton organization and biogenesis; regulation of axonogenesis; regulation of cell migration; regulation of osteoblast proliferation; regulation of small GTPase mediated signal transduction; Rho protein signal transduction; small GTPase mediated signal transduction; substantia nigra development; transforming growth factor beta receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; viral reproduction