Rabbit Anti-eIF-4A-II Polyclonal Antibody – Cat# MBS715093

Western blot
All lanes: Eukaryotic initiation factor 4A-II antibody at 2/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 44.5 kDa
Observed band size: 44.5 kDa

Eukaryotic Initiation Factor 4a-II (eIF-4A-II) Antibody – Rabbit Polyclonal

Name: eIF-4A-II Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS715093
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS715093

MBS715093 is an antibody targeting eIF-4A-II. Also known as Rabbit anti-human human Eukaryotic initiation factor 4A-II polyclonal Antibody. Reactive in Human. Host: Rabbit. More details

$230 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Eukaryotic initiation factor 4A-II (eIF-4A-II), Polyclonal Antibody

Full Product Name

Rabbit anti-human human Eukaryotic initiation factor 4A-II polyclonal Antibody

Product Gene Name

anti-eIF-4A-II antibody

Product Synonym Names

eIF4A-II; EC=3.6.4.13; ATP-dependent RNA helicase eIF4A-2

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Purity/Purification

Caprylic Acid Ammonium Sulfate Precipitation Purified

Preparation and Storage

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Matching Pairs

Unconjugated Antibody: eIF-4A-II (MBS715093)
HRP Conjugated Antibody: eIF-4A-II (MBS715096)

Matching Pairs

Unconjugated Antibody: eIF-4A-II (MBS715093)
FITC Conjugated Antibody: eIF-4A-II (MBS715491)

Molecular Weight

46,489 Da

OMIM

601102

3D Structure

ModBase 3D Structure for Q14240

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Conjugate

Non-conjugated

Immunogen

Recombinant human Eukaryotic initiation factor 4A-II protein

Santa Cruz Alternative

Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-14215

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-eIF-4A-II antibody

ELISA (EIA), Western Blot (WB)

Other Notes

Small volumes of anti-eIF-4A-II antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for eIF-4A-II. It may not necessarily be applicable to this product.

NCBI GI #

83700235

NCBI GeneID

1974

NCBI Accession #

NP_001958.2

UniProt Primary Accession #

Q14240

UniProt Secondary Accession #

Q53XJ6; Q96B90; Q96EA8; D3DNU9

UniProt Related Accession #

Q14240

GenBank Nucleotide #

NM_001967.3

NCBI Official Full Name

eukaryotic initiation factor 4A-II

NCBI Official Synonym Full Names

eukaryotic translation initiation factor 4A2

NCBI Official Symbol

EIF4A2

NCBI Official Synonym Symbols

DDX2B; EIF4A; EIF4F; BM-010; eIF4A-II; eIF-4A-II

UniProt Protein Name

Eukaryotic initiation factor 4A-II

UniProt Synonym Protein Names

ATP-dependent RNA helicase eIF4A-2

Protein Family

Eukaryotic initiation factor

UniProt Gene Name

EIF4A2

UniProt Synonym Gene Names

DDX2B; EIF4F; eIF-4A-II; eIF4A-II

UniProt Entry Name

IF4A2_HUMAN

NCBI Protein Information

eukaryotic initiation factor 4A-II

UniProt Comments for eIF-4A-II

EIF4A2: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Belongs to the DEAD box helicase family. eIF4A subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.13; Helicase; Translation initiation; RNA-binding; Translation

Chromosomal Location of Human Ortholog: 3q28

Cellular Component: cytosol; eukaryotic translation initiation factor 4F complex; perinuclear region of cytoplasm

Molecular Function: ATP binding; ATP-dependent RNA helicase activity; ATPase activity; helicase activity; protein binding; translation initiation factor activity

Biological Process: cellular protein metabolic process; cytokine and chemokine mediated signaling pathway; gene expression; mRNA catabolic process, deadenylation-dependent decay; poly(A) tail shortening; regulation of translational initiation; RNA secondary structure unwinding; translation; translational initiation; viral reproduction

Research Articles on eIF-4A-II

1. expression is an independent prognostic factor for patients with non-small-cell lung cancer for both overall survival and disease-free survival

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-eIF-4A-II antibody

Reference Product	PubMed Publications
EIF4A1 antibody	>6 publications with eIF-4A-II and EIF4A1
EIF4G1 antibody	>1 publications with eIF-4A-II and EIF4G1

Pathways associated with anti-eIF-4A-II antibody

Products by Pathway	Pathway Diagram
Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies	Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies	Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
Cap-dependent Translation Initiation Pathway antibodies	Cap-dependent Translation Initiation Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Deadenylation Of MRNA Pathway antibodies	Deadenylation Of MRNA Pathway Diagram
Deadenylation-dependent MRNA Decay Pathway antibodies	Deadenylation-dependent MRNA Decay Pathway Diagram
Eukaryotic Translation Initiation Pathway antibodies	Eukaryotic Translation Initiation Pathway Diagram
GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway antibodies	GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
ISG15 Antiviral Mechanism Pathway antibodies	ISG15 Antiviral Mechanism Pathway Diagram

Diseases associated with anti-eIF-4A-II antibody

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>2 publications with eIF-4A-II and Breast Neoplasms
Memory Disorders Antibodies	>1 publications with eIF-4A-II and Memory Disorders
Learning Disorders Antibodies	>1 publications with eIF-4A-II and Learning Disorders
Carcinoma, Squamous Cell Antibodies	>1 publications with eIF-4A-II and Carcinoma, Squamous Cell
Lung Diseases Antibodies	>1 publications with eIF-4A-II and Lung Diseases
Lung Neoplasms Antibodies	>1 publications with eIF-4A-II and Lung Neoplasms
Fibrosis Antibodies	>1 publications with eIF-4A-II and Fibrosis
Fatty Liver Antibodies	>1 publications with eIF-4A-II and Fatty Liver
Liver Diseases Antibodies	>1 publications with eIF-4A-II and Liver Diseases
Prenatal Exposure Delayed Effects Antibodies	>1 publications with eIF-4A-II and Prenatal Exposure Delayed Effects

Organs/Tissues associated with anti-eIF-4A-II antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>3 publications with eIF-4A-II and Liver
Muscle Antibodies	>3 publications with eIF-4A-II and Muscle
Brain Antibodies	>3 publications with eIF-4A-II and Brain
Blood Antibodies	>2 publications with eIF-4A-II and Blood
Ovary Antibodies	>1 publications with eIF-4A-II and Ovary
Pancreas Antibodies	>1 publications with eIF-4A-II and Pancreas
Lung Antibodies	>1 publications with eIF-4A-II and Lung
Embryonic Tissue Antibodies	>1 publications with eIF-4A-II and Embryonic Tissue
Kidney Antibodies	>1 publications with eIF-4A-II and Kidney
Uterus Antibodies	>1 publications with eIF-4A-II and Uterus