Rab GDP Dissociation Inhibitor Beta (GDI2) Antibody – Rabbit Polyclonal

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GDI2: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Belongs to the Rab GDI family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10p15

Cellular Component: cytoplasm; cytosol; focal adhesion; Golgi apparatus; membrane; myelin sheath; vesicle

Molecular Function: GTPase activator activity; oxidoreductase activity; protein binding; Rab GDP-dissociation inhibitor activity; small GTPase binding

Biological Process: positive regulation of GTPase activity; protein transport; regulation of small GTPase mediated signal transduction; signal transduction; small GTPase mediated signal transduction; vesicle-mediated transport