Ras-Related Protein Rab-1a (RAB1A) Antibody – Rabbit Polyclonal

This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]

RAB1A: Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity. Belongs to the small GTPase superfamily. Rab family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, monomeric, Rab; G protein, monomeric; G protein

Chromosomal Location of Human Ortholog: 2p14

Cellular Component: cytosol; early endosome; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; melanosome

Molecular Function: GTP binding; GTPase activity; protein binding

Biological Process: autophagic vacuole formation; autophagy; cell migration; cellular protein metabolic process; cilium biogenesis; COPII coating of Golgi vesicle; defense response to bacterium; endocytosis; ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; growth hormone secretion; melanosome transport; mitotic cell cycle; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine; small GTPase mediated signal transduction; vesicle transport along microtubule; vesicle-mediated transport; virus assembly