Rho GDP-Dissociation Inhibitor 1 (ARHGDIA) Antibody – Rabbit Polyclonal

This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

RhoGDI alpha: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Monomer. Forms a heterodimer with RAC1. Interacts with FER. Belongs to the Rho GDI family.

Protein type: Apoptosis; Motility/polarity/chemotaxis; Cell development/differentiation; G protein regulator, misc.; Cell adhesion

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: cytoskeleton; cytosol

Molecular Function: GTPase activator activity; protein binding; Rho GDP-dissociation inhibitor activity

Biological Process: cell motility; negative regulation of apoptosis; negative regulation of axonogenesis; negative regulation of cell adhesion; nerve growth factor receptor signaling pathway; positive regulation of axonogenesis; positive regulation of GTPase activity; regulation of axonogenesis; regulation of catalytic activity; regulation of small GTPase mediated signal transduction; Rho protein signal transduction; small GTPase mediated signal transduction

Disease: Nephrotic Syndrome, Type 8