Rabbit Anti-UQCRQ Polyclonal Antibody – Cat# MBS715328

Western blot All lanes: Cytochrome b-c1 complex subunit 8 antibody at at 2 /mlLane 1: EC109 whole cell lysateLane 2: 293T whole cell lysate SecondaryGoat polyclonal to Rabbit IgG at 1/15000 dilution Predicted band size: 9.5 kDa Observed band size: 30kDa Why is the actual band size different from the predicted Western blotting is a technique that separates proteins based on size - in general, the smaller the protein the faster it migrates through the gel. However, migration is also affected by other factors and so the actual band size observed may differ from that predicted. Common factors include... · post-translational modification - e.g. phosphorylation, glycosylation etc which increases the size of the protein · post-translation cleavage - e.g. many proteins are synthesized as pro-proteins, and then cleaved to give the active form, e.g. pro-caspases · splice variants - alternative splicing may create different sized proteins from the same gene · relative charge - the composition of amino acids (charged vs non-charged) multimers - e.g. dimerisation of a protein. This is usually prevented in reducing conditions, although strong interactions can result in the appearance of higher bands.

Cytochrome B-C1 Complex Subunit 8 (UQCRQ) Antibody – Rabbit Polyclonal

Name: UQCRQ Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS715328
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS715328

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone. More details

$230 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cytochrome b-c1 complex subunit 8 (UQCRQ), Polyclonal Antibody

Full Product Name

Rabbit anti-human Cytochrome b-c1 complex subunit 8 polyclonal Antibody, Biotin conjugated

Product Gene Name

anti-UQCRQ antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Purity/Purification

Caprylic Acid Ammonium Sulfate Precipitation

Preparation and Storage

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Matching Pairs

Unconjugated Antibody: b-c1 (MBS715150)
Biotin Conjugated Antibody: Cytochrome b-c1 complex subunit 8 (MBS715328)

Molecular Weight

9,906 Da

OMIM

612080

3D Structure

ModBase 3D Structure for O14949

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Conjugate

Biotin

Immunogen

Recombinant human Cytochrome b-c1 complex subunit 8 protein

Santa Cruz Alternative

Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-74880

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-UQCRQ antibody

ELISA (EIA)

Other Notes

Small volumes of anti-UQCRQ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UQCRQ purchase

MBS715328 is an antibody targeting UQCRQ. Also known as Rabbit anti-human Cytochrome b-c1 complex subunit 8 polyclonal Antibody, Biotin conjugated. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for UQCRQ. It may not necessarily be applicable to this product.

NCBI GI #

83367083

NCBI GeneID

27089

NCBI Accession #

NP_055217.2

UniProt Primary Accession #

O14949

UniProt Secondary Accession #

Q5FVE2; Q9BV88; Q9T2V7

UniProt Related Accession #

O14949

GenBank Nucleotide #

NM_014402.4

NCBI Official Full Name

cytochrome b-c1 complex subunit 8

NCBI Official Synonym Full Names

ubiquinol-cytochrome c reductase complex III subunit VII

NCBI Official Symbol

UQCRQ

NCBI Official Synonym Symbols

QPC; QCR8; QP-C; UQCR7; MC3DN4

UniProt Protein Name

Cytochrome b-c1 complex subunit 8

UniProt Synonym Protein Names

Complex III subunit 8; Complex III subunit VIII; Ubiquinol-cytochrome c reductase complex 9.5 kDa protein; Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C

Protein Family

Cytochrome b-c1 complex

UniProt Gene Name

UQCRQ

UniProt Entry Name

QCR8_HUMAN

NCBI Protein Information

cytochrome b-c1 complex subunit 8

NCBI Summary for UQCRQ

This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008]

UniProt Comments for UQCRQ

UQCRQ: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone. Defects in UQCRQ are a cause of mitochondrial complex III deficiency (MT-C3D). A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance. Belongs to the UQCRQ/QCR8 family.

Protein type: Mitochondrial; Energy Metabolism - oxidative phosphorylation; Oxidoreductase

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: mitochondrial inner membrane; mitochondrion

Molecular Function: ubiquinol-cytochrome-c reductase activity

Biological Process: cellular metabolic process; cerebellar Purkinje cell layer development; hippocampus development; hypothalamus development; midbrain development; pons development; pyramidal neuron development; subthalamus development; thalamus development

Disease: Mitochondrial Complex Iii Deficiency, Nuclear Type 4

Research Articles on UQCRQ

1. QP-C protein gene expression involved in the development of hyperpigmentation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UQCRQ antibody

Reference Product	PubMed Publications
CYC1 antibody	>2 publications with UQCRQ and CYC1
UQCRC2 antibody	>2 publications with UQCRQ and UQCRC2
UQCRB antibody	>2 publications with UQCRQ and UQCRB
UQCRH antibody	>1 publications with UQCRQ and UQCRH
COX5B antibody	>1 publications with UQCRQ and COX5B
UQCR10 antibody	>1 publications with UQCRQ and UQCR10
UQCRC1 antibody	>1 publications with UQCRQ and UQCRC1

Pathways associated with anti-UQCRQ antibody

Products by Pathway	Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Cytochrome Bc1 Complex Pathway antibodies	Cytochrome Bc1 Complex Pathway Diagram
Cytochrome Bc1 Complex Pathway antibodies	Cytochrome Bc1 Complex Pathway Diagram
Electron Transport Chain Pathway antibodies	Electron Transport Chain Pathway Diagram
Huntington's Disease Pathway antibodies	Huntington's Disease Pathway Diagram
Huntington's Disease Pathway antibodies	Huntington's Disease Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram

Diseases associated with anti-UQCRQ antibody

Disease Name	Pubmed Publications
Mitochondrial Complex III Deficiency Antibodies	>2 publications with UQCRQ and Mitochondrial Complex III Deficiency
Abnormalities, Multiple Antibodies	>1 publications with UQCRQ and Abnormalities, Multiple
Nervous System Diseases Antibodies	>1 publications with UQCRQ and Nervous System Diseases
Mental Disorders Antibodies	>1 publications with UQCRQ and Mental Disorders
Hypertension Antibodies	>1 publications with UQCRQ and Hypertension
Necrosis Antibodies	>1 publications with UQCRQ and Necrosis

Organs/Tissues associated with anti-UQCRQ antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>4 publications with UQCRQ and Muscle
Brain Antibodies	>3 publications with UQCRQ and Brain
Blood Antibodies	>2 publications with UQCRQ and Blood
Heart Antibodies	>2 publications with UQCRQ and Heart