TSPY-Like 2 (TSPYL2) Antibody – Rabbit Polyclonal

This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]

TSPYL2: Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. Belongs to the nucleosome assembly protein (NAP) family.

Protein type: DNA replication; Transcription regulation

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: nucleoplasm; centrosome; cytoplasm; nucleolus; plasma membrane; nucleus

Molecular Function: rDNA binding

Biological Process: transcription, DNA-dependent; unfolded protein response; regulation of signal transduction; chromatin modification; cell cycle; negative regulation of cell cycle; nucleosome assembly; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; regulation of transcription, DNA-dependent; negative regulation of DNA replication; negative regulation of cell growth; regulation of protein kinase activity