Discs, Large Homolog 3 (DLG3) Antibody – Rabbit Polyclonal

This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

DLG3: Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Interacts through its PDZ domains with NETO1, GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4. Interacts through its PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Belongs to the MAGUK family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: Xq13.1

Cellular Component: extracellular space; postsynaptic membrane; tight junction; growth cone; cell soma; basolateral plasma membrane; cytoplasm; postsynaptic density; plasma membrane; ionotropic glutamate receptor complex; dendritic shaft

Molecular Function: protein C-terminus binding; guanylate kinase activity; ionotropic glutamate receptor binding; protein binding; ubiquitin protein ligase binding; protein phosphatase binding; phosphatase binding; PDZ domain binding

Biological Process: establishment and/or maintenance of epithelial cell polarity; nervous system development; negative regulation of cell proliferation; synaptic transmission; axon guidance; establishment of planar polarity; receptor clustering; nucleotide phosphorylation

Disease: Mental Retardation, X-linked 90