SMARCA5 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. [provided by RefSeq, Jul 2008]

SMARCA5: an ubiquitous enzyme with ATP-dependent DNA helicase activity. Possesses intrinsic ATP-dependent nucleosome remodelling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin in vitro; this may require intact histone H4 tails. The catalytic subunit of the four known chromatin remodelling complexes: CHRAC, RSF, ACF/WCRF, and WICH. Each complex contains subunits which may regulate the specificity or catalytic activity of SMARCA5. Overexpressed in CD34-positive erythrocyte progenitor cells in acute myeloid leukemia. Down-regulation correlates with hematologic remission following chemotherapy. Belongs to the SNF2/RAD54 helicase family, ISWI subfamily.

Protein type: EC 3.6.4.-; EC 3.6.1.-; Histone-binding; Transcription factor; Helicase

Chromosomal Location of Human Ortholog: 4q31.1-q31.2

Cellular Component: nucleoplasm; chromatin silencing complex; RSF complex; nuclear replication fork; nucleolus; condensed chromosome; nucleus

Molecular Function: protein binding; DNA binding; histone binding; ATPase activity; nucleosome binding; helicase activity; ATP binding

Biological Process: chromatin silencing at rDNA; regulation of transcription from RNA polymerase II promoter; chromatin remodeling; nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; negative regulation of gene expression, epigenetic; double-strand break repair; transcription initiation; ATP-dependent chromatin remodeling; gene expression; regulation of gene expression, epigenetic; nucleosome positioning