Solute Carrier Organic Anion Transporter Family, Member 6a1 (SLCO6A1) Antibody – Rabbit Polyclonal

SLCO6A1: a multi-pass membrane protein strongly expressed in testis and weakly in spleen, brain, fetal brain and placenta. A member of the Cancer-Testis Antigen (CTA) superfamily. CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. Expressed in bladder, esophageal, brain and lung cancers. Spontaneous humoral immune responses have been detected in cancer patients. Belongs to the organo anion transporter (TC 2.A.60) family. Contains 1 Kazal-like domain. Note: This description may include information from RefSeq and UniProtKB

Protein type: Cancer Testis Antigen (CTA); Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 5q21.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function: transporter activity

Biological Process: transport