Helicase-Like Transcription Factor (HLTF) Antibody – Rabbit Polyclonal

This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008]

SMARCA3: an enzyme with apparent ATP-dependent DNA helicase activity. Belongs to the SNF2/RAD54 helicase family, RAD16 subfamily. Two alternatively spliced human isoforms have been described.

Protein type: Ubiquitin conjugating system; Ligase; EC 6.3.2.19; EC 3.6.1.-; EC 3.6.4.-; Nucleolus; Helicase; DNA-binding; Ubiquitin ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 3q25.1-q26.1

Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; ATPase activity; helicase activity; ATP binding; ligase activity

Biological Process: regulation of transcription from RNA polymerase II promoter; protein polyubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; postreplication repair; chromatin modification