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Xylosyltransferase I (XYLT1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS716222

MBS716222 is an antibody targeting XYLT1. Also known as Rabbit anti-human xylosyltransferase I polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$590 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
xylosyltransferase I (XYLT1), Polyclonal Antibody
Full Product Name
Rabbit anti-human xylosyltransferase I polyclonal Antibody
Product Gene Name
anti-XYLT1 antibody
Product Synonym Names
xylosyltransferase I; XYLT1; XT-I; XT1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze / thaw cycles
OMIM
gene 615777
3D Structure
ModBase 3D Structure for Q86Y38
Immunogen
Human XYLT1
Immunogen Species
Homo sapiens (Human)
Storage Buffer
0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-50870 / sc-50871 / sc-50872 / sc-134851
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-XYLT1 antibody
ELISA (EIA), Western Blot (WB)

Other Notes

Small volumes of anti-XYLT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for XYLT1. It may not necessarily be applicable to this product.

NCBI GI #
11322268
NCBI GeneID
64131
NCBI Accession #
CAC16787.1
UniProt Primary Accession #
Q86Y38
UniProt Secondary Accession #
Q9H1B6
UniProt Related Accession #
Q86Y38
NCBI Official Full Name
xylosyltransferase I, partial
NCBI Official Synonym Full Names
xylosyltransferase I
NCBI Official Symbol
XYLT1
NCBI Official Synonym Symbols
XT1; XTI; XT-I; DBQD2; XYLTI; PXYLT1
UniProt Protein Name
Xylosyltransferase 1
UniProt Synonym Protein Names
Peptide O-xylosyltransferase 1; Xylosyltransferase I; XT-I; XylT-I
Protein Family
Xylosyltransferase
UniProt Gene Name
XYLT1
UniProt Synonym Gene Names
XT1; XT-I; XylT-I
UniProt Entry Name
XYLT1_HUMAN
NCBI Protein Information
xylosyltransferase 1; xylT-I; O-xylosyltransferase 1; xylosyltransferase iota; beta-D-xylosyltransferase 1; peptide O-xylosyltransferase 1

NCBI Summary for XYLT1

This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum.[provided by RefSeq, Nov 2009]
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UniProt Comments for XYLT1

XYLT1: Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. Belongs to the glycosyltransferase 14 family. XylT subfamily.

Protein type: Membrane protein, integral; Glycan Metabolism - chondroitin sulfate biosynthesis; Glycan Metabolism - heparan sulfate biosynthesis; Transferase; EC 2.4.2.26

Chromosomal Location of Human Ortholog: 16p12.3

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; integral to membrane; extracellular region

Molecular Function: acetylglucosaminyltransferase activity; protein xylosyltransferase activity

Biological Process: glycosaminoglycan biosynthetic process; chondroitin sulfate biosynthetic process; heparan sulfate proteoglycan biosynthetic process

Disease: Desbuquois Dysplasia 2; Pseudoxanthoma Elasticum
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Research Articles on XYLT1

1. five distinct homozygous XYLT1 mutations may have a role in Desbuquois dysplasia type 2

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-XYLT1 antibody

 Products by Pathway  Pathway Diagram
 Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway Diagram
 Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway Diagram
 Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway antibodies  Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway Diagram
 Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway antibodies  Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway Diagram
 Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway antibodies  Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway Diagram
 Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway antibodies  Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Chondroitin Sulfate Biosynthesis Pathway antibodies  Chondroitin Sulfate Biosynthesis Pathway Diagram
 Chondroitin Sulfate Biosynthesis Pathway antibodies  Chondroitin Sulfate Biosynthesis Pathway Diagram

Diseases associated with anti-XYLT1 antibody

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >2 publications with XYLT1 and Fibrosis
 Abnormalities, Multiple Antibodies  >1 publications with XYLT1 and Abnormalities, Multiple
 Liver Diseases Antibodies  >1 publications with XYLT1 and Liver Diseases
 Disease Models, Animal Antibodies  >1 publications with XYLT1 and Disease Models, Animal

Organs/Tissues associated with anti-XYLT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >5 publications with XYLT1 and Bone
 Blood Antibodies  >4 publications with XYLT1 and Blood
 Connective Tissue Antibodies  >3 publications with XYLT1 and Connective Tissue
 Skin Antibodies  >2 publications with XYLT1 and Skin
 Muscle Antibodies  >1 publications with XYLT1 and Muscle
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