Zinc Fingers and Homeoboxes 2 (ZHX2) Antibody – Rabbit Polyclonal

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]

ZHX2: Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. Belongs to the ZHX family.

Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 8q24.13

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; nucleus

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; metal ion binding; transcription corepressor activity; transcription factor activity

Biological Process: negative regulation of neuron differentiation; transcription, DNA-dependent; somatic stem cell maintenance; mRNA catabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent