Wiskott-Aldrich Syndrome-Like (WASL) Antibody – Rabbit Polyclonal

This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]

N-WASP: Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2. Interacts with the C-terminal SH3 domain of DNMBP. Interacts with SNX9. Interacts with the WW domains of PRPF40A/FBP11. Interacts with PTK2/FAK1. Interacts with NOSTRIN. Interacts with Shigella flexneri protein IcsA. The interaction with IcsA enhances the affinity of WASL for Arp2/3, thus assembling a tight complex which has maximal activity in actin assembly. Interacts with E.coli effector protein EspF(U). Identified in a complex containing at least WASL, BAIAP2L1 and E.coli EspF(U). Binds to TNK2.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q31.3

Cellular Component: lamellipodium; cytoplasmic membrane-bound vesicle; plasma membrane; cytosol; nucleus; actin cap; actin cytoskeleton

Molecular Function: protein binding; actin binding

Biological Process: positive regulation of filopodium formation; axon guidance; mitosis; transcription, DNA-dependent; vesicle organization and biogenesis; nitric oxide metabolic process; spindle localization; vesicle transport along actin filament; regulation of protein localization; regulation of transcription, DNA-dependent; response to bacterium; cell division; actin polymerization and/or depolymerization; ephrin receptor signaling pathway; innate immune response; protein complex assembly; regulation of nitric-oxide synthase activity; cell motility; membrane budding