Protein Kinase C, Iota (PRKCI) Antibody – Rabbit Polyclonal

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]

PKCI: an AGC protein kinase of the PKC family. A calcium-independent, phospholipid-dependent atypical protein kinase C. Is not activated by phorbolesters or diaglycerol. May play role in the secretory response to nutrients. Involved in cell polarization processes and the formation of epithelial tight junctions. Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Tumor suppressor; Kinase, protein; EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); Oncoprotein; Protein kinase, AGC; Cell development/differentiation; AGC group; PKC family; Iota subfamily

Chromosomal Location of Human Ortholog: 3q26.3

Cellular Component: Golgi membrane; microtubule cytoskeleton; intercellular bridge; tight junction; protein complex; apical plasma membrane; cytoplasm; leading edge; plasma membrane; cytosol; nucleus; endosome

Molecular Function: protein domain specific binding; protein serine/threonine kinase activity; protein binding; protein kinase C activity; metal ion binding; phospholipid binding; ATP binding; protein kinase activity

Biological Process: intercellular junction assembly and maintenance; cell migration; secretion; nerve growth factor receptor signaling pathway; establishment of apical/basal cell polarity; actin filament organization; cytoskeleton organization and biogenesis; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; establishment and/or maintenance of epithelial cell polarity; vesicle-mediated transport; positive regulation of glucose import; eye photoreceptor cell development; cellular response to insulin stimulus; negative regulation of neuron apoptosis; Golgi vesicle budding; protein targeting to membrane; negative regulation of apoptosis