Eukaryotic Translation Termination Factor 1 (ETF1) Antibody – Rabbit Polyclonal

This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]

ETF1: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Belongs to the eukaryotic release factor 1 family.

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; RNA binding; translation termination factor activity; translation release factor activity; ribosome binding; translation release factor activity, codon specific

Biological Process: cellular protein metabolic process; protein amino acid methylation; translation; mRNA catabolic process, nonsense-mediated decay; gene expression; translational termination; regulation of translational termination