Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Beta (PIP4K2B) Antibody – Rabbit Polyclonal

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]

PIP4K2B: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex. Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; Kinase, lipid; EC 2.7.1.149

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: nucleoplasm; endoplasmic reticulum membrane; plasma membrane; cytosol

Molecular Function: 1-phosphatidylinositol-4-phosphate 5-kinase activity; receptor signaling protein activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; ATP binding

Biological Process: cell surface receptor linked signal transduction; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process