Dynein Light Chain 1 (DYNLL1) Human Recombinant Protein

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Binds and inhibits the catalytic activity of neuronal nitric oxide synthase. Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.

Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster.Dick T., Ray K., Salz H.K., Chia W.Mol. Cell. Biol. 16:1966-1977(1996) Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions.Song C., Wen W., Rayala S.K., Chen M., Ma J., Zhang M., Kumar R.J. Biol. Chem. 283:4004-4013(2008) Biochemical and structural characterization of the Pak1-LC8 interaction.Lightcap C.M., Sun S., Lear J.D., Rodeck U., Polenova T., Williams J.C.J. Biol. Chem. 283:27314-27324(2008) Lysine acetylation targets protein complexes and co-regulates major cellular functions.Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.Science 325:834-840(2009) Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A.Garcia-Mayoral M.F., Martinez-Moreno M., Albar J.P., Rodriguez-Crespo I., Bruix M.FEBS J. 277:2340-2350(2010) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment.Dunsch A.K., Linnane E., Barr F.A., Gruneberg U.J. Cell Biol. 192:959-968(2011) ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression.Jurado S., Conlan L.A., Baker E.K., Ng J.L., Tenis N., Hoch N.C., Gleeson K., Smeets M., Izon D., Heierhorst J.J. Biol. Chem. 287:3156-3164(2012) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014) Structure of the PIN/LC8 dimer with a bound peptide.Liang J., Jaffrey S.R., Guo W., Snyder S.H., Clardy J.Nat. Struct. Biol. 6:735-740(1999) Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation.Gallego P., Velazquez-Campoy A., Regue L., Roig J., Reverter D.J. Biol. Chem. 288:12283-12294(2013)

Small volumes of DYNLL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS717105 is a recombinant protein targeting DYNLL1. Also known as Recombinant Human Dynein light chain 1, cytoplasmic protein. Host: E Coli.