CTDNEP1 Recombinant Protein – Cat# MBS717127

CTD Nuclear Envelope Phosphatase 1 (CTDNEP1) Recombinant Protein

Name: CTDNEP1 Recombinant Protein; MyBioSource
Brand: MyBioSource
SKU: MBS717127
Price: 910 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS717127

Serine/threonine phosphatase which may be required for proper nuclear membrane morphology. Involved in LPIN1 dephosphorylation. May antagonize BMP signaling. More details

$910 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CTD nuclear envelope phosphatase 1 (CTDNEP1), Recombinant Protein

Full Product Name

Recombinant human CTD nuclear envelope phosphatase 1 protein

Product Gene Name

CTDNEP1 recombinant protein

Product Synonym Names

Serine/threonine-protein phosphatase dullard

Sequence

RTQCLLGLRT FVAFAAKLWS FFIYLLRRQI RTVIQYQTVR YDILPLSPVS RNRLAQVKRK ILVLDLDETL IHSHHDGVLR PTVRPGTPPD FILKVVIDKH PVRFFVHKRP HVDFFLEVVS QWYELVVFTA SMEIYGSAVA DKLDNSRSIL KRRYYRQHCT LELGSYIKDL SVVHSDLSSI VILDNSPGAY RSHPDNAIPI KSWFSDPSDT ALLNLLPMLD ALRFTADVRS VLSRNLHQHR LW

Host

E Coli

Form/Format

Liquid containing glycerol

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage,conserve at -20 degree C or -80 degree C.

Molecular Weight

54 KD

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 17; NC_000017.10 (7146906..7155259, complement). Location: 17p13

OMIM

610684

3D Structure

ModBase 3D Structure for O95476

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for CTDNEP1 recombinant protein

SDS-PAGE, ELISA (EIA)

Other Notes

Small volumes of CTDNEP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTDNEP1 purchase

MBS717127 is a recombinant protein targeting CTDNEP1. Also known as Recombinant human CTD nuclear envelope phosphatase 1 protein. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CTDNEP1. It may not necessarily be applicable to this product.

NCBI GI #

219555647

NCBI GeneID

23399

NCBI Accession #

NP_056158.2

UniProt Primary Accession #

O95476

UniProt Secondary Accession #

Q96GQ9; D3DTN7

UniProt Related Accession #

O95476

GenBank Nucleotide #

NM_015343.4

NCBI Official Full Name

Homo sapiens CTD nuclear envelope phosphatase 1 (CTDNEP1), transcript variant 1, mRNA

NCBI Official Synonym Full Names

CTD nuclear envelope phosphatase 1

NCBI Official Symbol

CTDNEP1

NCBI Official Synonym Symbols

NET56; DULLARD; HSA011916

UniProt Protein Name

CTD nuclear envelope phosphatase 1

UniProt Synonym Protein Names

Serine/threonine-protein phosphatase dullard

Protein Family

CTD nuclear envelope phosphatase

UniProt Gene Name

CTDNEP1

UniProt Synonym Gene Names

DULLARD

UniProt Entry Name

CNEP1_HUMAN

NCBI Protein Information

CTD nuclear envelope phosphatase 1; dullard homolog; serine/threonine-protein phosphatase dullard; C-terminal domain nuclear envelope phosphatase 1

UniProt Comments for CTDNEP1

Function: Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling. Ref.7 Ref.8

Catalytic activity: A phosphoprotein + H2O = a protein + phosphate.

Subunit structure: Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2. Ref.8

Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein Ref.2 Ref.7 Ref.8.

Tissue specificity: Muscle specific with lower expression in other metabolic tissues. Ref.8

Sequence similarities: Belongs to the dullard family.Contains 1 FCP1 homology domain.

Biophysicochemical propertiesKinetic parameters:KM=18 mM for p-nitrophenylphosphate Ref.7pH dependence:Optimum pH is 5.5.

Research Articles on CTDNEP1

1. dullard shows specificity for the peptide corresponding to the insulin-dependent phosphorylation site (Ser106) of lipin

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with CTDNEP1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>4 publications with CTDNEP1 and Nerve
Bone Antibodies	>1 publications with CTDNEP1 and Bone
Embryonic Tissue Antibodies	>1 publications with CTDNEP1 and Embryonic Tissue