CXCL10 Recombinant Protein – Cat# MBS717319

C-X-C Motif Chemokine 10 (CXCL10) Recombinant Protein

Name: CXCL10 Recombinant Protein; MyBioSource
Brand: MyBioSource
SKU: MBS717319
Price: 255 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS717319

MBS717319 is a recombinant protein targeting CXCL10. Also known as Recombinant human C-X-C motif chemokine 10 protein. Host: E Coli. Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. More details

$255 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

C-X-C motif chemokine 10 (CXCL10), Recombinant Protein

Full Product Name

Recombinant human C-X-C motif chemokine 10 protein

Product Gene Name

CXCL10 recombinant protein

Product Synonym Names

C-X-C motif chemokine 10 His tagged; 10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10

Sequence

VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP-

Host

E Coli

Form/Format

Liquid containing glycerol

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store working aliquots at 4 degree C for up to one week. For extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended.

Molecular Weight

15 kDa

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 4; NC_000004.11 (76942269..76944689, complement). Location: 4q21

OMIM

147310

3D Structure

ModBase 3D Structure for P02778

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for CXCL10 recombinant protein

SDS-PAGE, ELISA

Product References and Citations for CXCL10 recombinant protein

[1] "Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins." Luster A.D., Unkeless J.C., Ravetch J.V. Nature 315:672-676(1985) [PubMed: 3925348] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2] "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[3] "Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8." Proost P., de Wolf-Peeters C., Conings R., Opdenakker G., Billiau A., van Damme J. J. Immunol. 150:1000-1010(1993) [PubMed: 8423327] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-51.
[4] "Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)." Tensen C.P., Flier J., van der Raaij-Helmer E.M.H., Sampat-Sardjoepersad S., van der Schors R.C., Leurs R., Scheper R.J., Boorsma D.M., Willemze R. J. Invest. Dermatol. 112:716-722(1999) [PubMed: 10233762] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-29. Tissue: Keratinocyte.
[5] "Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity." Hensbergen P.J., van der Raaij-Helmer E.M.H., Dijkman R., van der Schors R.C., Werner-Felmayer G., Boorsma D.M., Scheper R.J., Willemze R., Tensen C.P. Eur. J. Biochem. 268:4992-4999(2001) [PubMed: 11559369] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-27; 60-67 AND 79-98, MASS SPECTROMETRY, IDENTIFICATION OF CXCL10(1-73). Tissue: Foreskin keratinocyte.

Other Notes

Small volumes of CXCL10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCL10. It may not necessarily be applicable to this product.

NCBI GI #

149999382

NCBI GeneID

3627

NCBI Accession #

NP_001556.2

UniProt Primary Accession #

P02778

UniProt Secondary Accession #

Q96QJ5

UniProt Related Accession #

P02778

GenBank Nucleotide #

NM_001565.3

NCBI Official Full Name

C-X-C motif chemokine 10

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 10

NCBI Official Symbol

CXCL10

NCBI Official Synonym Symbols

C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10

UniProt Protein Name

C-X-C motif chemokine 10

UniProt Synonym Protein Names

10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10

Protein Family

C-X-C motif chemokine

UniProt Gene Name

CXCL10

UniProt Synonym Gene Names

INP10; SCYB10; Gamma-IP10; IP-10

UniProt Entry Name

CXL10_HUMAN

NCBI Protein Information

C-X-C motif chemokine 10; gamma IP10; gamma-IP10; small-inducible cytokine B10; interferon-inducible cytokine IP-10; 10 kDa interferon gamma-induced protein; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X-Cys), member 10

NCBI Summary for CXCL10

This gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Jul 2008]

UniProt Comments for CXCL10

Function: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.

Subcellular location: Secreted.

Induction: By IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response.

Post-translational modification: CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes.

Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.

Mass spectrometry: Molecular mass is 8641.8 Da from positions 22 - 98. Determined by ESI. Ref.5

Research Articles on CXCL10

1. Type 1 diabetes mellitus (T1DM) children had a stronger seropositivity towards MAP3738c protein and serum activity towards the specific protein of Mycobacterium avium subsp. paratuberculosis and the increase of CXCL10 concentration, was also reported.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CXCL10 recombinant protein

Reference Product	PubMed Publications
CXCL9 recombinant protein	>781 publications with CXCL10 and CXCL9
CXCR3 recombinant protein	>719 publications with CXCL10 and CXCR3
CCL5 recombinant protein	>550 publications with CXCL10 and CCL5
CXCL11 recombinant protein	>394 publications with CXCL10 and CXCL11
CCR5 recombinant protein	>156 publications with CXCL10 and CCR5
CCL11 recombinant protein	>91 publications with CXCL10 and CCL11
CCL20 recombinant protein	>91 publications with CXCL10 and CCL20
CCL21 recombinant protein	>55 publications with CXCL10 and CCL21
CCR3 recombinant protein	>46 publications with CXCL10 and CCR3
CCR1 recombinant protein	>43 publications with CXCL10 and CCR1

Pathways associated with CXCL10 recombinant protein

Products by Pathway	Pathway Diagram
CXCR3-mediated Signaling Events Pathway antibodies	CXCR3-mediated Signaling Events Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with CXCL10 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>925 publications with CXCL10 and Inflammation
Necrosis Antibodies	>554 publications with CXCL10 and Necrosis
Neoplasms Antibodies	>381 publications with CXCL10 and Neoplasms
Lung Diseases Antibodies	>273 publications with CXCL10 and Lung Diseases
Liver Diseases Antibodies	>175 publications with CXCL10 and Liver Diseases
Cardiovascular Diseases Antibodies	>144 publications with CXCL10 and Cardiovascular Diseases
Fibrosis Antibodies	>106 publications with CXCL10 and Fibrosis
Neoplasms, Experimental Antibodies	>101 publications with CXCL10 and Neoplasms, Experimental
Kidney Diseases Antibodies	>73 publications with CXCL10 and Kidney Diseases
Drug Toxicity Antibodies	>55 publications with CXCL10 and Drug Toxicity

Organs/Tissues associated with CXCL10 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1701 publications with CXCL10 and Blood
Lung Antibodies	>384 publications with CXCL10 and Lung
Liver Antibodies	>216 publications with CXCL10 and Liver
Kidney Antibodies	>145 publications with CXCL10 and Kidney
Lymph Node Antibodies	>142 publications with CXCL10 and Lymph Node
Muscle Antibodies	>101 publications with CXCL10 and Muscle
Intestine Antibodies	>75 publications with CXCL10 and Intestine
Nerve Antibodies	>53 publications with CXCL10 and Nerve
Uterus Antibodies	>28 publications with CXCL10 and Uterus
Placenta Antibodies	>20 publications with CXCL10 and Placenta