IL15 Recombinant Protein – Cat# MBS717324

Interleukin-15 (IL15) Recombinant Protein

Name: IL15 Recombinant Protein; Interleukin-15; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS717324
Price: 255 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS717324

Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha. More details

$255 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin-15 (IL15), Recombinant Protein

Full Product Name

Recombinant human Interleukin-15 protein

Product Gene Name

IL15 recombinant protein

Product Synonym Names

Interleukin-15 His tagged

Sequence

NWVNVISDLK KIEDLIQSMH IDATLYTESD VHPSCKVTAM KCFLLELQVI SLESGDASIH DTVENLIILA NNSLSSNGNV TESGCKECEE LEEKNIKEFL QSFVHIVQMF INTS

Host

E Coli

Form/Format

Liquid containing glycerol

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store working aliquots at 4 degree C for up to one week. For extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended.

Molecular Weight

19 kDa

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 8; NC_010450.3 (90964030..90974054, complement). Location: 8; 8

3D Structure

ModBase 3D Structure for Q95253

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for IL15 recombinant protein

SDS-PAGE, ELISA

Product References and Citations for IL15 recombinant protein

[1] "Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor." Grabstein K.H., Eisenman J., Shanebeck K., Rauch C., Srinivasan S., Fung V., Beers C., Richardson J., Schoenborn M.A., Ahdieh M., Johnson L., Alderson M.R., Watson J.D., Anderson D.M., Giri J.G. Science 264:965-968(1994) [PubMed: 8178155] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IL15-S48AA). Tissue: Bone marrow.
[2] "Genomic sequence and chromosomal location of the human interleukin-15 gene (IL15)." Krause H., Jandrig B., Wernicke C., Bulfone-Paus S., Pohl T., Diamantstein T. Cytokine 8:667-674(1996) [PubMed: 8932977] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3] "Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines." Meazza R., Verdiani S., Biassoni R., Coppolecchia M., Gaggero A., Orengo A.M., Colombo M.P., Azzarone B., Ferrini S. Oncogene 12:2187-2192(1996) [PubMed: 8668345] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IL15-S21AA). Tissue: Lung cancer.
[4] "Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides." Tagaya Y., Kurys G., Thies T.A., Losi J.M., Azimi N., Hanover J.A., Bamford R.N., Waldmann T.A. Proc. Natl. Acad. Sci. U.S.A. 94:14444-14449(1997) [PubMed: 9405632] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IL15-S21AA). Tissue: Testis.
[5] "Expression of two IL-15 mRNA isoforms in human tumors does not correlate with secretion: role of different signal peptides." Meazza R., Ferrini S. Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Other Notes

Small volumes of IL15 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL15 purchase

MBS717324 is a recombinant protein targeting IL15. Also known as Recombinant human Interleukin-15 protein. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL15. It may not necessarily be applicable to this product.

NCBI GI #

47523834

NCBI GeneID

397683

NCBI Accession #

NP_999555.1

UniProt Primary Accession #

Q95253

UniProt Secondary Accession #

Q195F8

UniProt Related Accession #

Q95253

GenBank Nucleotide #

NM_214390.1

NCBI Official Full Name

interleukin-15

NCBI Official Symbol

IL15

NCBI Official Synonym Symbols

IL-15

UniProt Protein Name

Interleukin-15

Protein Family

Interleukin

UniProt Gene Name

IL15

UniProt Synonym Gene Names

IL-15

UniProt Entry Name

IL15_PIG

NCBI Protein Information

interleukin-15

UniProt Comments for IL15

Function: Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha

By similarity.

Subcellular location: Secreted.

Sequence similarities: Belongs to the IL-15/IL-21 family.

Research Articles on IL15

1. results demonstrate that porcine reproductive and respiratory syndrome virus (PRRSV)infection could induce IL-15 production in macrophages/dendritic cells; data further show that upregulation of IL-15 by PRRSV requires PKC and NF-kappaB pathways

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IL15 recombinant protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
HTLV-I Infection Pathway antibodies	HTLV-I Infection Pathway Diagram
HTLV-I Infection Pathway antibodies	HTLV-I Infection Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram

Diseases associated with IL15 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>444 publications with IL15 and Neoplasms
Necrosis Antibodies	>315 publications with IL15 and Necrosis
Inflammation Antibodies	>301 publications with IL15 and Inflammation
Disease Models, Animal Antibodies	>149 publications with IL15 and Disease Models, Animal
Death Antibodies	>127 publications with IL15 and Death
Nervous System Diseases Antibodies	>93 publications with IL15 and Nervous System Diseases
Lung Diseases Antibodies	>90 publications with IL15 and Lung Diseases
Neoplasms, Experimental Antibodies	>88 publications with IL15 and Neoplasms, Experimental
Hematologic Diseases Antibodies	>80 publications with IL15 and Hematologic Diseases
Liver Diseases Antibodies	>49 publications with IL15 and Liver Diseases

Organs/Tissues associated with IL15 recombinant protein

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>141 publications with IL15 and Intestine
Liver Antibodies	>102 publications with IL15 and Liver
Adipose Tissue Antibodies	>32 publications with IL15 and Adipose Tissue
Embryonic Tissue Antibodies	>28 publications with IL15 and Embryonic Tissue
Ovary Antibodies	>9 publications with IL15 and Ovary
Mammary Gland Antibodies	>1 publications with IL15 and Mammary Gland