Rhombotin-1 (LMO1) Human Recombinant Protein

May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.

The t(11;14) (p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein.McGuire E.A., Hockett R.D., Pollock K.M., Bartholdi M.F., O'Brien S.J., Korsmeyer S.J.Mol. Cell. Biol. 9:2124-2132(1989) An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs.Boehm T., Greenberg J.M., Buluwela L., Lavenir I., Forster A., Rabbitts T.H.EMBO J. 9:857-868(1990) T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells.McGuire E.A., Davis A.R., Korsmeyer S.J.Blood 77:599-606(1991) Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1) .Cichutek A., Brueckmann T., Seipel B., Hauser H., Schlaubitz S., Prawitt D., Hankeln T., Schmidt E.R., Winterpacht A., Zabel B.U.Cytogenet. Cell Genet. 93:277-283(2001) Human chromosome 11 DNA sequence and analysis including novel gene identification.Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.Nature 440:497-500(2006) Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin evidence for thymus expression.Boehm T., Spillantini M.G., Sofroniew M.V., Surani M.A., Rabbitts T.H.Oncogene 6:695-703(1991)

Small volumes of LMO1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS717388 is a recombinant protein targeting LMO1. Also known as Recombinant Human Rhombotin-1. Host: E Coli.