Human COMMD4 Recombinant Protein – Cat# MBS717404

COMM Domain-Containing Protein 4 (COMMD4) Human Recombinant Protein

Name: COMMD4 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS717404
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS717404

MBS717404 is a recombinant protein targeting COMMD4. Also known as Recombinant Human COMM domain-containing protein 4 (COMMD4), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

COMM domain-containing protein 4 (COMMD4), Recombinant Protein

Full Product Name

Recombinant Human COMM domain-containing protein 4 (COMMD4), partial

Product Gene Name

COMMD4 recombinant protein

Product Synonym Names

COMD4_HUMAN; COMM domain containing 4; COMM domain-containing protein 4; COMMD4

Sequence

MRFRFCGDLD CPDWVLAEIS TLAKMSSVKL RLLCSQVLKE LLGQGIDYEK ILKLTADAKF ESGDVKATVA VLSFILSSAA KHSVDGESLS SELQQLGLPK EHAASLCRCY EEKQSPLQKH LRVCSLRMNR LAGVGWRVDY TLSSSLLQSV EEPMVHLRLE VAAAPGTPAQ PVAMSLSADK FQVLLAELKQ AQTLM

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

12,291 Da

Sequence Positions

1-195aa, Partial

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for Q9H0A8

Species

Homo sapiens (Human)

Subcellular Location

Cytoplasm, Nucleus

Tissue Specificity

Ubiquitous.

Relevance

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B.

Function

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 degree C/-80 degree C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Product Categories/Family for COMMD4 recombinant protein

Cell Biology

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for COMMD4 recombinant protein

COMMD proteins, a novel family of structural and functional homologs of MURR1.Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S.J. Biol. Chem. 280:22222-22232(2005)
https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:26027
https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=351327
https://www.genome.jp/dbget-bin/www_bget?hsa:54939
https://string-db.org/network/9606.ENSP00000267935
https://www.omim.org/entry/616701616701616701

Other Notes

Small volumes of COMMD4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for COMMD4. It may not necessarily be applicable to this product.

NCBI GI #

548923849

NCBI GeneID

54939

NCBI Accession #

NP_001271306.1

UniProt Primary Accession #

Q9H0A8

UniProt Secondary Accession #

Q7L637; Q9NX43; B2RBN4; H3BUL2

UniProt Related Accession #

Q9H0A8

GenBank Nucleotide #

NM_001284377.1

NCBI Official Full Name

COMM domain-containing protein 4 isoform 2

NCBI Official Synonym Full Names

COMM domain containing 4

NCBI Official Symbol

COMMD4

UniProt Protein Name

COMM domain-containing protein 4

Protein Family

COMM domain-containing protein

UniProt Gene Name

COMMD4

UniProt Entry Name

COMD4_HUMAN

NCBI Protein Information

COMM domain-containing protein 4

UniProt Comments for COMMD4

COMMD4: Down-regulates activation of NF-kappa-B. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 15q24.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with COMMD4 recombinant protein

Reference Product	PubMed Publications
COMMD1 recombinant protein	>1 publications with COMMD4 and COMMD1

Organs/Tissues associated with COMMD4 recombinant protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>2 publications with COMMD4 and Muscle
Heart Antibodies	>1 publications with COMMD4 and Heart
Blood Antibodies	>1 publications with COMMD4 and Blood
Intestine Antibodies	>1 publications with COMMD4 and Intestine