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Transferrin Receptor Protein 1 (TFRC) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS717415

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a… More details

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Product Overview

Online Datasheet in PDF
Product Name
Transferrin receptor protein 1 (TFRC), Recombinant Protein
Full Product Name
Recombinant Human Transferrin receptor protein 1
Product Gene Name
TFRC recombinant protein
Product Synonym Gene Name
sTfR
Product Synonym Names
T9p90; CD71
Sequence
PKTECERLAG TESPVREEPG EDFPAARRLY WDDLKRKLSE KLDSTDFTGT IKLLNENSYV PREAGSQKDE NLALYVENQF REFKLSKVWR DQHFVKIQVK DSAQNSVIIV DKNGRLVYLV ENPGGYVAYS KAATVTGKLV HANFGTKKDF EDLYTPVNGS IVIVRAGKIT FAEKVANAES LNAIGVLIYM DQTKFPIVNA ELSFFGHAHL GTGDPYTPGF PSFNHTQFPP SRSSGLPNIP VQTISRAAAE KLFGNMEGDC PSDWKTDSTC RMVTSESKNV KLTVSNVLKE IKILNIFGVI KGFVEPDHYV VVGAQRDAWG PGAAKSGVGT ALLLKLAQMF SDMVLKDGFQ PSRSIIFASW SAGDFGSVGA TEWLEGYLSS LHLKAFTYIN LDKAVLGTSN FKVSASPLLY TLIEKTMQNV KHPVTGQFLY QDSNWASKVE KLTLDNAAFP FLAYSGIPAV SFCFCEDTDY PYLGTTMDTY KELIERIPEL NKVARAAAEV AGQFVIKLTH DVELNLDYER YNSQLLSFVR DLNQYRADIK EMGLSLQWLY SARGDFFRAT SRLTTDFGNA EKTDRFVMKK LNDRVMRVEY HFLSPYVSPK ESPFRHVFWG SGSHTLPALL ENLKLRKQNN GAFNETLFRN QLALATWTIQ GAANALSGDV W
Host
E Coli
Form/Format
Liquid containing glycerol
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
101.3kD
Sequence Positions
94-754
OMIM
190010
3D Structure
ModBase 3D Structure for P02786
Product Note
Applications are user defined. Product is developed and quality control tested in house, data or additional information may be provided upon request. The researcher needs to establish and confirm the suitability of the product for their application.

Product Categories/Family for TFRC recombinant protein

Immunology; Raw Materials Assay Development
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of TFRC recombinant protein

Human TFRC Recombinant Protein – Cat# MBS717415

Product References and Citations for TFRC recombinant protein

Primary structure of human transferrin receptor deduced from the mRNA sequence.Schneider C., Owen M.J., Banville D., Williams J.G.Nature 311:675-678(1984) The human transferrin receptor gene genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence.McClelland A., Kuhn L.C., Ruddle F.H.Cell 39:267-274(1984) Exon/intron structure of the human transferrin receptor gene.Evans P., Kemp J.Gene 199:123-131(1997) Molecular and evolutionary studies of the transferrin receptor.Wheeler D.L.Thesis (1999) , University of Iowa, United States Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. NIEHS SNPs program

Other Notes

Small volumes of TFRC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TFRC purchase

MBS717415 is a recombinant protein targeting TFRC. Also known as Recombinant Human Transferrin receptor protein 1. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TFRC. It may not necessarily be applicable to this product.

NCBI GI #
189458819
NCBI GeneID
7037
NCBI Accession #
NP_001121620.1
UniProt Primary Accession #
P02786
UniProt Secondary Accession #
Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21; D3DXB0
UniProt Related Accession #
P02786
GenBank Nucleotide #
NM_001128148.2
NCBI Official Full Name
transferrin receptor protein 1 isoform 1
NCBI Official Synonym Full Names
transferrin receptor
NCBI Official Symbol
TFRC
NCBI Official Synonym Symbols
T9; TR; TFR; p90; CD71; TFR1; TRFR
UniProt Protein Name
Transferrin receptor protein 1
UniProt Synonym Protein Names
T9; p90; CD_antigen: CD71
Protein Family
Transferrin receptor protein
UniProt Gene Name
TFRC
UniProt Synonym Gene Names
TR; TfR; TfR1; Trfr; sTfR
UniProt Entry Name
TFR1_HUMAN
NCBI Protein Information
transferrin receptor protein 1

NCBI Summary for TFRC

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

UniProt Comments for TFRC

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.

Protein type: Membrane protein, integral; Receptor, misc.; Cell surface

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: basolateral plasma membrane; cell surface; coated pit; cytoplasmic membrane-bound vesicle; endosome; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; melanosome; membrane; mitochondrion; perinuclear region of cytoplasm; plasma membrane; recycling endosome; recycling endosome membrane

Molecular Function: chaperone binding; double-stranded RNA binding; glycoprotein binding; Hsp70 protein binding; identical protein binding; protein binding; protein homodimerization activity; transferrin receptor activity; transferrin transmembrane transporter activity; viral receptor activity

Biological Process: acute-phase response; aging; cellular iron ion homeostasis; entry of virus into host cell; osteoclast differentiation; positive regulation of bone resorption; receptor-mediated endocytosis; regulation of cell growth; regulation of cell proliferation; response to copper ion; response to hypoxia; response to iron ion; response to manganese ion; response to nutrient; response to retinoic acid; transferrin transport; transmembrane transport
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Research Articles on TFRC

1. This study provides insights into the effector functions of human IgG3 in the context of an antibody targeting TfR1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TFRC recombinant protein

 Reference Product  PubMed Publications
 HFE recombinant protein  >21 publications with TFRC and HFE
 B2M recombinant protein  >16 publications with TFRC and B2M
 MYC recombinant protein  >14 publications with TFRC and MYC
 SLC40A1 recombinant protein  >10 publications with TFRC and SLC40A1
 FTH1 recombinant protein  >3 publications with TFRC and FTH1
 UBC recombinant protein  >3 publications with TFRC and UBC
 HIF1A recombinant protein  >3 publications with TFRC and HIF1A
 STEAP3 recombinant protein  >2 publications with TFRC and STEAP3
 OPTN recombinant protein  >1 publications with TFRC and OPTN

Pathways associated with TFRC recombinant protein

 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Iron Metabolism In Placenta Pathway antibodies  Iron Metabolism In Placenta Pathway Diagram

Diseases associated with TFRC recombinant protein

 Disease Name  Pubmed Publications
 Iron Metabolism Disorders Antibodies  >34 publications with TFRC and Iron Metabolism Disorders
 Disease Models, Animal Antibodies  >17 publications with TFRC and Disease Models, Animal
 Anemia, Iron-Deficiency Antibodies  >12 publications with TFRC and Anemia, Iron-Deficiency
 Inflammation Antibodies  >12 publications with TFRC and Inflammation
 Lung Neoplasms Antibodies  >10 publications with TFRC and Lung Neoplasms
 Liver Diseases Antibodies  >9 publications with TFRC and Liver Diseases
 Breast Neoplasms Antibodies  >7 publications with TFRC and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >7 publications with TFRC and Cardiovascular Diseases
 Colorectal Neoplasms Antibodies  >6 publications with TFRC and Colorectal Neoplasms
 Obesity Antibodies  >6 publications with TFRC and Obesity

Organs/Tissues associated with TFRC recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >54 publications with TFRC and Blood
 Liver Antibodies  >30 publications with TFRC and Liver
 Brain Antibodies  >29 publications with TFRC and Brain
 Lung Antibodies  >15 publications with TFRC and Lung
 Intestine Antibodies  >14 publications with TFRC and Intestine
 Bone Antibodies  >14 publications with TFRC and Bone
 Kidney Antibodies  >10 publications with TFRC and Kidney
 Skin Antibodies  >9 publications with TFRC and Skin
 Embryonic Tissue Antibodies  >8 publications with TFRC and Embryonic Tissue
 Vascular Antibodies  >7 publications with TFRC and Vascular
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